The EMS Lighthouse Project


Episode E43 – mRNA Vaccines – Real World Efficacy

We saw the amazing performance of the two mRNA COVID vaccines from Pfizer and Moderna in their RCTs. As encouraging as trial performance is, we always want to see how those numbers hold up under large scale, real-world pragmatic conditions. Well, we now have three new pieces of information on that. And, for the cherry on top, we get evidence of performance against asymptomatic infection! Dr. Jarvis does a quick review of the latest evidence on vaccine performance.



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Show Notes

Papers reviewed:

  1. Amit S, Beni SA, Biber A, Grinberg A, Leshem E, Regev-Yochay G. Postvaccination COVID-19 among Healthcare Workers, Israel. Emerg Infect Dis 2021; 27, 1220-1222.
  2. Dagan N, Barda N, Kepten E et al. BNT162b2 mRNA Covid-19 Vaccine in a Nationwide Mass Vaccination Setting. N Engl J Med 2021;
  3. Thompson MG. Interim Estimates of Vaccine Effectiveness of BNT162b2 and mRNA- 1273 COVID-19 Vaccines in Preventing SARS-CoV-2 Infection Among Health Care Personnel, First Responders, and Other Essential and Frontline Workers — Eight U.S. Locations, December 2020–March 2021. MMWR Morb Mortal Wkly Rep 2021;
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